sergey bezrukov nih
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sergey bezrukov nih

23 Oct sergey bezrukov nih

Angew Chem Int Ed Engl. Weinrich M, Worcester DL, Bezrukov SM. Address: NICHD/NIH 29 Lincoln Drive Building 29B, Room 1H16C Bethesda, MD 20892. Dr. Bezrukov’s honors include election to Fellowship in the American Physical Society (2009), the NIH Director’s Award in Science and Medicine (2010), and appointment to the Senior Biomedical Research Service (2011). In 1992, he joined the National Institutes of Health as a visiting scientist. Sergey M. Bezrukov is a Senior Investigator and chief of the Section on Molecular Transport, Program in Physical Biology, NICHD/NIH, a position he has held since October 2002. Sergey M. Bezrukov, PhD. Talent und Charisma dieses Schauspielers können nicht in Frage gestellt werden. Empirical findings obtained in these experiments are rationalized within a framework of a physical theory of channel-facilitated transport that brings understanding necessary to design new strategies to effectively correct the deviant interactions associated with disease. Sergey Bezrukov ist einer der beliebtestenRussische Schauspieler von Theater und Kino. He was awarded tenure by NIH in 2002. Hoogerheide DP, Gurnev PA, Rostovtseva TK, Bezrukov SM. Nicht alle Zuschauer wissen, dass Sergey Bezrukovs Wachstum ziemlich klein ist. We study mitochondrial and bacterial membrane proteins that form “large” beta-barrel channels responsible for metabolite fluxes between cells and cellular compartments. In contrast to the highly ion-selective channels studied in neurophysiology, which have narrow selectivity filters to match the size of partially dehydrated ions, metabolite, or “nutrient” channels are significantly wider. This allows us to explore channel interactions with the lipid membrane as modified by volatile anesthetics, by cytosolic proteins, such as tubulin and alpha-synuclein, and by newly synthesized drugs that act as blockers of the translocation pores of bacterial toxins. Outside of the lab, Gurnev was known as a loyal friend who could be counted on in a crisis. in Condensed Matter Physics from the St. Petersburg Nuclear Physics Institute of the Russian Academy of Sciences. This line of research serves as the basis for the development of new approaches to treatment of diseases where regulation of transport through ion channels plays the key role. In particular, we are interested in the physical mechanisms of their functioning and regulation under normal and pathological conditions. Sergey M. Bezrukov, PhD. Bezrukov Lab: Section on Molecular Transport, Get the latest public health information from CDC: https://www.coronavirus.gov Get the latest research information from NIH: https://www.nih.gov/coronavirus NIH staff guidance on coronavirus (NIH Only): https://employees.nih.gov/pages/coronavirus, Address:NICHD/NIH 29 Lincoln DriveBuilding 29B, Room 1H16CBethesda, MD 20892. This line of research serves as the basis for the development of new approaches to treatment of many diseases where regulation of transport through ion channels plays the key role. Phone: 301-402-4701 We study mitochondrial and bacterial membrane proteins that form “large” beta-barrel channels responsible for metabolite fluxes between cells and cellular compartments. Dr. Bezrukov received his M.S. You are here: Home > Bezrukov Lab Biophysics of Large Membrane Channels. Dr. Bezrukov’s section combines physical theory with experiments on bacterial, mitochondrial, and toxin-induced membrane channels, reconstituted in planar lipid bilayers, in order to address fundamental questions of membrane transport. Mechanism of alpha-synuclein translocation through a VDAC nanopore revealed by energy landscape modeling of escape time distributions. Dr. Bezrukov has authored numerous scientific papers, five of them published in Nature (London). Dr. Sergey Michael Bezrukov received his M.S. My choice to work on ion channels—membrane-perforating proteins—was probably driven by the unique combination of their apparent conceptual simplicity and the many challenges of nano-scale physics used for their description. Flux through a stochastically gated channel, Figure 3. Bezrukov Lab: Section on Molecular Transport, Get the latest public health information from CDC: https://www.coronavirus.gov Get the latest research information from NIH: https://www.nih.gov/coronavirus NIH staff guidance on coronavirus (NIH Only): https://employees.nih.gov/pages/coronavirus, Address:NICHD/NIH 29 Lincoln DriveBuilding 29B, Room 1H16CBethesda, MD 20892, Dr. Alexander M. Berezhkovskii, Mathematical and Statistical Computing Laboratory, CIT, Dr. Alexandra Beilina, Laboratory of Neurogenetics, NIA, Dr. Susan K. Buchanan, Structural Biology of Membrane Proteins Section, NIDDK, Dr. Leonid Chernomordik, Laboratory of Cellular and Molecular Biophysics, PPB/NICHD, Dr. Mark R. Cookson, Laboratory of Neurogenetics, NIA, Dr. Sanjay A. Desai, Laboratory of Malaria and Vector Research, NIAID, Dr. Jennifer Lee, Biochemistry and Biophysics Center, NHLBI, Dr. Stephen H. Leppla, Microbial and Pathogenesis Section, NIAID, Dr. Kamran C. Melikov, Laboratory of Cellular and Molecular Biophysics, PPB/NICHD, Dr. Caroline Philpott, Genetics and Metabolism Section, Liver Diseases Branch, NIDDK, Dr. Olga Protchenko, Genetics and Metabolism Section, Liver Diseases Branch, NIDDK, Dr. Michael Weinrich, National Center for Medical Rehabilitation Research, NICHD, Dr. Joshua J. Zimmerberg, Laboratory of Cellular and Molecular Biophysics, PPB/NICHD, Dr. Jeff Abramson, Department of Physiology, David Geffen School of Medicine, UCLA, CA, Dr. Andrew Crain, Sanford-Burnham Medical Research Institute, La Jolla, CA, Dr. Roderic G. Eckenhoff, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, Dr. Jens Gundlach, Department of Physics, University of Washington, Seattle, WA, Dr. David Hoogerheide, NIST, Gaithersburg, MD, Dr. Vladimir Karginov, Innovative Biologics, Inc., Manassas, VA, Dr. Laszlo B. Kish, Department of Electrical Engineering, Texas A&M University, College Station, TX, Dr. Alfredo Quinones-Hinojosa, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, Dr. John J. Lemasters, Medical University of South Carolina, Charleston, SC, Dr. Kim Lewis, Department of Biology, Northeastern University, Boston, MA, Dr. Eduardo Maldonado, Medical University of South Carolina, Charleston, SC, Dr. Ekaterina M. Nestorovich, Department of Biology, The Catholic University of America, Washington, DC, Dr. V. Adrian Parsegian, Physics Department, University of Massachusetts, Amherst, MA, Dr. Horia I. Petrache, Physics Department, IUPUI, Indianapolis, IN, Dr. Jon Y. Takemoto, Department of Biology, Utah State University, Logan, UT, Dr. David L. Worcester, NIST and Department of Physiology and Biophysics, University of California, Irvine, CA, Dr. Vicente M. Aguilella, Universidad Jaume I, Castellon, Spain, Dr. Holger Barth, Institute of Pharmacology and Toxicology, University of Ulm, Germany, Dr. Leonardo Dagdug, Departamento de Fisica, Universidad Autonoma, Mexico City, Mexico, Dr. Vito De Pinto, University of Catania, Catania, Italy, Dr. Daniel Harries, Hebrew University of Jerusalem, Jerusalem, Israel. Polyethylene glycols in semidilute regime: radius of gyration in the bulk and partitioning into a nanopore. Indeed, they have to accommodate metabolite molecules that typically are much larger than simple mono- or divalent ions. FOIA, Figure 1. α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease. Bezrukov Lab: Section on Molecular Transport, Get the latest public health information from CDC: https://www.coronavirus.gov Get the latest research information from NIH: https://www.nih.gov/coronavirus NIH staff guidance on coronavirus (NIH Only): https://employees.nih.gov/pages/coronavirus, Address:NICHD/NIH 29 Lincoln DriveBuilding 29B, Room 1H16CBethesda, MD 20892, Section on Molecular TransportEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bldg. Address: NICHD/NIH 29 Lincoln Drive Building 29B, Room 1H16C Bethesda, MD 20892. Among many wet-lab approaches such as fluorescence correlation spectroscopy, bilayer overtone analysis, and confocal microscopy, our hallmark method is reconstitution of these proteins into planar lipid membranes that allows us to study them at the single-molecule level. Mean direct-transit and looping times as functions of the potential shape. Address: NICHD/NIH 29 Lincoln Drive Building 29B, Room 1H16C Bethesda, MD 20892. Cation-selective channel is regulated by anions according to their Hofmeister ranking. {"serverDuration": 196, "requestCorrelationId": "eb61b73ec4d473e2"}, US Department of Health and Human Services, https://employees.nih.gov/pages/coronavirus. Born in 1978, Gurnev received his Ph.D. in physiology in 2003 from the Institute of Cytology of the Russian Academy of Sciences, St. Petersburg. Device for Simulating Explosive Blast Trauma Ref: E-068-2012-0 | Updated: Mar 2, 2012 | NICHD. in physics and mathematics from the Russian Academy of Sciences. J Biol Chem. 2018;114(5):1026-1029. Sergey Bezrukov: Filmografie des Sterns. He has organized and chaired many international meetings and workshops. He has organized and chaired many international meetings and workshops. 2017;56(13):3506-3509. We also use Gramicidin A (linear pentadecapeptide from Bacillus brevis) as a molecular sensor of membrane mechanical properties. You are here: Home > Bezrukov Lab Biophysics of Large Membrane Channels. 29B, Room 1H16CBethesda, MD 20892Telephone: (301) 402-4701Fax: (301) 496-2172Email: bezrukos@mail.nih.gov. For NIH Staff Only Office of Technology Transfer, Office of Intramural Research, National Institutes of Health 6011 Executive Blvd, Suite 325, Rockville, MD 20852 | Phone: 301-496-7057 Structural features and lipid binding domain of tubulin on biomimetic mitochondrial membranes. Sergey M. Bezrukov is a Senior Investigator and chief of the Section on Molecular Transport, Program in Physical Biology, NICHD/NIH, a position he has held since October 2002. Nestorovich EM, Bezrukov SM. Gurnev PA, Roark TC, Petrache HI, Sodt AJ, Bezrukov SM. Real-time nanopore-based recognition of protein translocation success. He is a member of the Supreme Council of the party United Russia With the goal to study the channel-forming proteins under controlled conditions, we first isolate them from the host organisms, purify, and then reconstitute into planar lipid bilayers, the model system with precisely defined physical properties. Sergey M. Bezrukov, PhD. in physics from St. Petersburg Polytechnic University, Russia, his Ph.D. in biophysics from Moscow State University, and a D.Sci. Expert Opin Drug Discov. α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease. Gurnev made significant contributions to the field of ion channel biophysics in the lab of Dr. Sergey Bezrukov. Hoogerheide DP, Noskov SY, Jacobs D, Bergdoll L, Silin V, Worcester D, Abramson J, Nanda H, Rostovtseva TK, Bezrukov SM.

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